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Presenter:  Kate Hayden

Discussion summary:

We discussed Kulkarni et al., J. Lipid Res. 1994, 35, 159.  The paper describes a new method for the analysis of plasma lipoproteins (HDL, LDL, VLDL, IDL, and Lp[a]) using the Vertical Auto Profile II method, based on ultracentrifugation at ~37,000 g and using only 18-40 ul of blood plasma.  High resolution and minimal analysis time were achieved.  This test is very important for heart health, and optimization of its implementation led to a successful company startup and growth.

Points that were discussed:

  • Meaning of reproducibility scores
  • Need to do cholesterol/triglyceride analyses along with lipoprotein profiles
  • Lipoprotein unit meanings
  • Changes in the method from 1980-2010